Hi Paul, and Welcome to the forum!
Congratulations on your project!
Starlight is already giving you good advice, so I'll just add some more comments to what he already said.
...host small jazz and rock groups. I'm expecting no more than 110db max sound levels.
For jazz, that's probably about right, maybe even a little high, but for contemporary rock groups the levels could go higher than that. It's not unusual to be approaching 120 dBC inside the room, especially if you have a heavy-hitting drummer, and a bass player who likes to "turn it up to 11". To be certain what your real levels will be, it would be good if you could take a sound level meter into your next practice session with your band, and measure the actual levels in there (set the meter to "C" weighting, and "Slow" response).
The building will be a converted 20' x 24' X 12' 6" free-standing pre-fab two-car garage/workshop
That's a nice size! Especially the height: having a high ceiling is always good for live instruments. It seems like your studio can be quite good, acoustically!
My plan is to add mass to the exterior (it's just sheathing and OSB) with two layers of 5/8" drywall between the studs.
That is often called "beefing up the mass", and there's a simple procedure for doing that: cut the strips of drywall just a fraction smaller than the stud bay, press it in place against the OSB, caulk around the edges (with any good-quality kitchen or bathroom caulk that is very flexible and remains soft and rubbery even when fully cured), then use "cleats" nailed sideways into the studs, to hold the drywall in place. Don't nail through the drywall into the OSB! So the drywall will just be pressed up against the OSB, held in place by the cleats, and sealed around the edges with caulk. If you want even better isolation, the use Green Glue compound between the drywall and OSB, then again between the second layer of drywall and the first. Green Glue is effective, and works as advertised, but it's not cheap.
Will build room-in-a-room with staggered studs, two layers of 5/8" Fire X with Green Glue on the inner leaf,
Your mention of staggered studs makes me wonder if you might be misunderstanding the concept of "room in a room". You only need a total of two "leaves" here, and your existing garage IS the outer leaf. Or rather, it will be the outer leaf once you "beef it up", as above. So you only need one additional leaf to complete the system: just a simple single-stud frame with drywall on only one side of that frame (not both sides). That's your second leaf: the "inner" leaf. In other words, there is no need for a staggered stud frame here.
Here's a diagram to show you the concept:
That doesn't show exactly your situation: rather, it shows the situation where somebody wants to section off part of the garage or basement to use as a studio. But you can still see how this works. In your case, the inner room (at the back) would be larger, filling the entire garage space, and you would not need the partition wall that sections off that part... I'm sure you can picture that in your mid. Think of it like a "matchbox inside a shoe-box". The "shoe-box" is your existing garage shell (beefed up), and the "matchbox" is what you build inside of that.
and about a 3" air space between the exterior and interior walls.
There's some simple equations for calculating the optimum size for the air space, based on the amount of isolation you need, and the frequency range you need to isolate. This type of construction creates a tuned system that resonates at a low frequency, so it is important to design it so that the frequency is low enough. The air gap is a key part of that. I should also mention that this whole "air gap" thing is also confusing, since there are several things that this term could refer to, but the important distance here is the distance across the wall cavity from the outer leaf to the inner leaf, and not just the distance between the two frames. In other words, i you imagine that you could shrink yourself down small enough to stand inside the cavity, then take out a tape measure and measure the distance across the cavity, from the surface of the outer-leaf drywall to the surface of the inner-leaf drywall: That's what you need to know. That's part of what controls the resonant frequency I was talking about above. The bigger that distance is, the lower the frequency is, and the better your isolation is. Assuming typical 2x4 stud framing for both leaves, and a 2" gap between the frames, that would give you a total cavity depth of 9": 3 1/2" for each stud depth, =7, plus the 2" gap between frames, = 9. (In your case, it would be a bit less since you will be "beefing up" the outer leaf with 2 layers of 5/8" drywall, so the cavity would be 1 1/4" less, or about 7 3/4"). That would probably be fine for your case, but it would be good to put some real numbers together here, and do the actual calculations, to make sure that it will do what you want it to do.
I want to build an airlock-type entry, ...
You can if you want, but you don't really need to. The normal way of dealing with doors in a 2-laf system like this, is simply to have a pair of doors back-to-back: one door in the inner leaf, and the other in the outer leaf. There's a thread about that here on the forum:
site built door for high isolation That shows the usual way of doing that.
Of course, if you really wanted to have a "chamber" between the doors big enough to stand in, so you can close one door behind you before opening the other, then you can do that. Not a problem. In that case, you would just build out a closet-sized section of the wall, protruding into the room, and put the inner-leaf door on that. I can sketch that up for you roughly if you want, but not right now: It's nearly 3 AM where I am, and I need to get some sleep!
2. Can I use a standard solid-core metal exterior door as the exterior door (the outer leaf) while using a solid wood door for the inner leaf?
You can, yes. No problem. As long as you do what Starlight mentioned, and make sure that you have enough mass in each door, to match the mass of the wall ("surface density" is the more correct technical term here, but most people just talk about "mass"....)
3. For the beefing of the exterior wall, what's the best way to fasten the drywall to the OSB?
The best way is to NOT fasten it to the OSB!
To maximize isolation, each layer in the leaf needs to be able to move independently, so it can flex and "wobble" by itself, but in conjunction with the other layers. If you screw them all firmly together, they they cannot act separately, and you lose a bit of isolation. So the method for "beefing up" that I mentioned above just has the drywall pressed up against the OSB, and held in place with small cleats that you nail sideways into the STUDS, not into the OSB. That way, the entire drywall panel is free to move any way it wants to. Of course, you do have to seal the edges air-tight, and that's what the caulk is for.
I saw the example in Rod's book of the caulk-in-place, but I'm not sure if that was the only thing holding the two drywall layers there.
The caulk, plus the cleats. I'll see if I can find some photos of how my clients have done that in the past, so you can see how it works in practice.
I think that's everything, although I'm sure I missed something.
The ceiling?
Sound moves in all three dimensions, so your isolation plan must also be in three dimensions. Here too the existing roof of the garage is probably going to be your outer-leaf, so you might need to figure out how to beef that up the same as the outer-leaf wall, then you would build an inner-leaf ceiling that rests on top of the inner-leaf walls, to complete the system. One caveat here: roofs are often designed to be "ventilated deck", where air is supposed to come in under the eaves, flow past under the actual roof deck, then exit our through a ridge vent or gable end vents. If you have a roof done like that, you cannot use that as your outer-leaf, and you will need to build a "three-leaf" system up there. It's not as terrible as it sounds! If you can post some photos of your room, and especially of your roof, that would help to identify what you have, and figure out what the solution would be.
One more thing you might have missed here, is HVAC. I wrote an article about that a while back:
why your studio needs HVAC. Take a look at that: it's rather important!
- Stuart -